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A Comparison of Previous Antibiotic Therapy Following Isolation of MRSA Versus MSSA in Nursing Home Residents. Susceptibilities of Haemophilus influenzae and Moraxella catarrhalis to ABT-773 compared to their susceptibilities to 11 other agents.The activity of the ketolide ABT-773 against Haemophilus and Moraxella was compared to those of 11 other agents. Antibiotic exposure is a risk factor for isolation of methicillin-resistant Staphylococcus aureus (MRSA). MSSA was always/usually sensitive to dicloxacillin, amoxicillin/clavulanate, cephalosporins, imipenem, quinolones, and erythromycin, whereas MRSA was always/usually resistant. One in the screening group versus 2 controls had received a nontargeted antibiotic. Against 210 Haemophilus influenzae strains (39.0% beta-lactamase positive), microbroth dilution tests sho that azithromycin ( Zithromax ) and ABT-773 had the lowest MICs (0.5 to 4.0 and 1.0 to 8.0 microg/ml, respectively), follo by clarithromycin and roxithromycin (4.0 to >32.0 antibiotics bacteria virus prescription medicines microg/ml). The use of nontargeted antibiotics was low, with greater use in the MRSA clinical group. The association was especially strong for quinolones with urinary or wound isolation of MRSA.
Forty-eight prescription medicines cases with initial MRSA clinical isolates (15 urinary, 19 wound, 11 sputum, 3 blood) were matched to 48 with MSSA clinical isolates from the same location. amoxycillin The comparison of antibiotic exposure in the 48 clinical isolates revealed that 29 (60%) with MRSA isolates versus 16 (33%) with MSSA isolates aciclovir had received a targeted antibiotic (RR 1.81, CI 1.33-3.34, P 0.006). Our data do not support the hypothesis that targeted antibiotic use was more likely to be associated with MRSA isolation than nontargeted antibiotic use. Twenty-one (62%) of 34 with MRSA (urine or wound) isolates versus 4 MSSA controls (12%) had received a quinolone (RR 5.25, CI 1.80-15.30, P |
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